diff --git a/packages/angular-query-experimental/src/__tests__/inject-mutation.test-d.ts b/packages/angular-query-experimental/src/__tests__/inject-mutation.test-d.ts
index e241ce58c94..f83774a0525 100644
--- a/packages/angular-query-experimental/src/__tests__/inject-mutation.test-d.ts
+++ b/packages/angular-query-experimental/src/__tests__/inject-mutation.test-d.ts
@@ -72,4 +72,13 @@ describe('injectMutation', () => {
       >()
     })
   })
+
+  it('should allow calling mutate with no arguments when TVariables is optional undefinable', () => {
+    const mutation = injectMutation(() => ({
+      mutationFn: (_variables: number | undefined) => sleep(0).then(() => 1),
+    }))
+
+    expectTypeOf(mutation.mutate).toBeCallableWith()
+    expectTypeOf(mutation.mutateAsync).toBeCallableWith()
+  })
 })
diff --git a/packages/preact-query/src/__tests__/useMutation.test-d.tsx b/packages/preact-query/src/__tests__/useMutation.test-d.tsx
index 7b7a5806058..cba067db9db 100644
--- a/packages/preact-query/src/__tests__/useMutation.test-d.tsx
+++ b/packages/preact-query/src/__tests__/useMutation.test-d.tsx
@@ -79,6 +79,15 @@ describe('useMutation', () => {
     expectTypeOf(mutation.mutate).toBeCallableWith()
   })
 
+  it('should allow calling mutate with no arguments when TVariables is optional undefinable', () => {
+    const mutation = useMutation({
+      mutationFn: (_variables: number | undefined) => Promise.resolve(1),
+    })
+
+    expectTypeOf(mutation.mutate).toBeCallableWith()
+    expectTypeOf(mutation.mutateAsync).toBeCallableWith()
+  })
+
   it('should infer custom TError type', () => {
     class CustomError extends Error {
       code: number
diff --git a/packages/react-query/src/__tests__/useMutation.test-d.tsx b/packages/react-query/src/__tests__/useMutation.test-d.tsx
index 7b7a5806058..cba067db9db 100644
--- a/packages/react-query/src/__tests__/useMutation.test-d.tsx
+++ b/packages/react-query/src/__tests__/useMutation.test-d.tsx
@@ -79,6 +79,15 @@ describe('useMutation', () => {
     expectTypeOf(mutation.mutate).toBeCallableWith()
   })
 
+  it('should allow calling mutate with no arguments when TVariables is optional undefinable', () => {
+    const mutation = useMutation({
+      mutationFn: (_variables: number | undefined) => Promise.resolve(1),
+    })
+
+    expectTypeOf(mutation.mutate).toBeCallableWith()
+    expectTypeOf(mutation.mutateAsync).toBeCallableWith()
+  })
+
   it('should infer custom TError type', () => {
     class CustomError extends Error {
       code: number
diff --git a/packages/solid-query/src/__tests__/useMutation.test-d.tsx b/packages/solid-query/src/__tests__/useMutation.test-d.tsx
index 9bc689ea9b0..b5ae427d6e8 100644
--- a/packages/solid-query/src/__tests__/useMutation.test-d.tsx
+++ b/packages/solid-query/src/__tests__/useMutation.test-d.tsx
@@ -79,6 +79,15 @@ describe('useMutation', () => {
     expectTypeOf(mutation.mutate).toBeCallableWith()
   })
 
+  it('should allow calling mutate with no arguments when TVariables is optional undefinable', () => {
+    const mutation = useMutation(() => ({
+      mutationFn: (_variables: number | undefined) => Promise.resolve(1),
+    }))
+
+    expectTypeOf(mutation.mutate).toBeCallableWith()
+    expectTypeOf(mutation.mutateAsync).toBeCallableWith()
+  })
+
   it('should infer custom TError type', () => {
     class CustomError extends Error {
       code: number
diff --git a/packages/svelte-query/tests/createMutation/createMutation.test-d.ts b/packages/svelte-query/tests/createMutation/createMutation.test-d.ts
index 4ea6027949e..a5a4bd8419a 100644
--- a/packages/svelte-query/tests/createMutation/createMutation.test-d.ts
+++ b/packages/svelte-query/tests/createMutation/createMutation.test-d.ts
@@ -79,6 +79,15 @@ describe('createMutation', () => {
     expectTypeOf(mutation.mutate).toBeCallableWith()
   })
 
+  it('should allow calling mutate with no arguments when TVariables is optional undefinable', () => {
+    const mutation = createMutation(() => ({
+      mutationFn: (_variables: number | undefined) => Promise.resolve(1),
+    }))
+
+    expectTypeOf(mutation.mutate).toBeCallableWith()
+    expectTypeOf(mutation.mutateAsync).toBeCallableWith()
+  })
+
   it('should infer custom TError type', () => {
     class CustomError extends Error {
       code: number
diff --git a/packages/vue-query/src/__tests__/useMutation.test-d.tsx b/packages/vue-query/src/__tests__/useMutation.test-d.tsx
index 8433c72c4d4..80d8996e982 100644
--- a/packages/vue-query/src/__tests__/useMutation.test-d.tsx
+++ b/packages/vue-query/src/__tests__/useMutation.test-d.tsx
@@ -84,3 +84,16 @@ describe('Discriminated union return type', () => {
     expectTypeOf(mutation.variables).toEqualTypeOf<string>()
   })
 })
+
+describe('useMutation', () => {
+  it('should allow calling mutate with no arguments when TVariables is optional undefinable', () => {
+    const mutation = reactive(
+      useMutation({
+        mutationFn: (_variables: number | undefined) => sleep(0).then(() => 1),
+      }),
+    )
+
+    expectTypeOf(mutation.mutate).toBeCallableWith()
+    expectTypeOf(mutation.mutateAsync).toBeCallableWith()
+  })
+})